Research suggests acupuncture is a safe and effective treatment for obesity. Various forms of acupuncture may help, including ear and electro-acupuncture. The stimulation of ear acupuncture points has been shown to suppress appetite. In one trial over three quarters of those who received stimulation of acupuncture points lost over 2Kg in weight over the 12 week treatment period. Treatment at least once weekly, and preferably more frequently, for at least 2 months, is likely to be necessary to result in significant weight loss. Inevitably successful weight loss is far more likely to be achieved if acupuncture is combined with dietary and lifestyle changes. Research suggests that acupuncture probably works to help weight loss in part by suppressing the appetite. In addition there is a hormone produced in the brain called nesfatin-1 that helps control obesity. Levels of the hormone are reduced in those who are overweight or obese. Acupuncture has been shown to increase levels of nesfatin-1 and thus help in weight reduction.